How To Improve RbAp48 Protein Levels in the Brain?

If higher RbAp48 levels reduce chance of old age memory loss, then how do we get more?

Albert Einstein sticking out his tongue A recent study made headlines by suggesting that the amount of RbAp48 protein in the brain effects age related memory loss. I wrote an article about the study for this blog and received several hits on the article. Seems the keywords that led people to my article were ‘foods containing RbAp48’, ‘source of RbAp48’ and “supplements for RbAp48’. 

Apparently, people are concerned about age related memory loss and want to do something about it.

Therefore, I decided to explore ways to add more protein RbAp48 to the brain and found a potential few results. It is valid to keep in mind, that the recent study concluding that RbAp48 protein levels relates to memory loss and the studies on increasing that protein discussed here do not preclude a cure. I am merely a blogger who looks stuff up and then writes about it, not a medical professional.

A reference to a dissertation study involving mice suggests that three ‘drugs’ may increase RbAp48 protein in the hippocampus brain and improve age related memory loss.

Are there RbAp48 Protein Supplements?

1. Epicatechin or catechin is a flavan-3-ol previously researched for treatment of cancer and for speeding up metabolism for weight loss. Catechin food sources include the highest levels in green tea, cocoa and in fruit skins such as grapes and blackberries. This does not mean you just eat chocolate as sugar is detrimental to health, however, cocoa can be used as seasoning.

More Food Sources from
Unfermented green tea offers the most catechin content, with about 27 percent catechin. Oolong tea has 23 percent, and black tea around 4 percent. Levels of EC are concentrated in foods like raw apples, apricots, nectarines, pears and plums with skin, blackberries, red raspberries, cranberries, cherries and broad beans. Dark chocolate has over twice the amount of EC found in berries. Barley, raisins, red wine and rhubarb are also good sources of catechin

2. Sodium butyrate is a short-chain fatty acid, also with possible cancer fighting abilities. A natural byproduct of fermentation of fiber in the gut seems to work as a detox of ammonia and neurotoxins as well as improving healthy bacteria growth for digestion.

Sodium Butyrate Explanation from
Butyrate is a fatty acid that is produced by anaerobic bacteria fermentation of dietary fiber, such as cellulose, in your colon. It can combine with sodium to form a salt that is called sodium butyrate. The natural function of butyrate in your colon is not fully understood, but it acts as a powerful detoxifier of ammonia and neurotoxins and it encourages the formation of “friendly” or symbiotic bacteria in the gastrointestinal tract, according to the book “Human Biochemistry”. It has been suggested that butyrate may also inhibit the development of colon cancer, although human research is lacking

3. SAHA stands for suberoylanilide hydroxamic acid the chemotherapy drug known as Vorinostat. Vorinostat is able to pass through the blood barrier of the brain and is used to treat cutaneous T-cell lymphoma (CTCL, a type of cancer) in people whose disease has not improved, has gotten worse, or has come back after taking other medications. Vorinostat is available exclusively as a prescription drug and relatively unproven as age related memory loss treatment, not an option for self-treatment.

The wise choice would be, add green tea, cocoa, fruit, and fiber to a healthy diet low in sugar, high in protein and healthy fats.
  • Regular exercise has been proven many times to maintain cognitive ability and reasoning. Exercise may allow the brain to produce new neurons. 
  • Get outside, as natural vitamin D is beneficial to health and the brain. 
  • The brain responds to being used therefore use it. Learn something often, read, and do puzzles. Recent studies show improved mental abilities in senior citizens playing video games. 
  • Avoid toxins in the air, water, and in your food. Prepackaged processed foods contain many potential toxins and unhealthy chemicals. 
  • Sleep also has been proven vital to memory and brain function in many studies. 

It always comes back to eat healthy, exercise more and get better sleep, perhaps the three main ingredients to a healthy and vital long life.

Update: A new study suggests caffeine improves long term memory.


Take care and be well.
Tommy Douglas 

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